کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561192 1560834 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cisplatin resistance and opportunities for precision medicine
ترجمه فارسی عنوان
مقاومت سیس پلاتین و فرصت های پزشکی دقیق
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. The use of precision medicine to make informed decisions on a patient’s cisplatin resistance status and predicting the tumor response would allow the clinician to tailor the chemotherapy program based on the biology of the disease. In this review, key biomarkers of each molecular mechanism will be discussed along with the current clinical research. Additionally, known polymorphisms for each biomarker will be discussed in relation to their influence on cisplatin resistance.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 106, April 2016, Pages 27–36
نویسندگان
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