کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561407 1126914 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nonsteroidal antiinflammatory drugs: Past, present and future
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Nonsteroidal antiinflammatory drugs: Past, present and future
چکیده انگلیسی

Currently available NSAIDs represent a heterogeneous group of therapeutic agents characterized by a variable benefit/risk profile. The development of a new class of selective COX-2 inhibitors, the coxibs, has contributed importantly to clarifying the discrete roles of COX-2 vs. COX-1 inhibition in different aspects of NSAID-related efficacy and safety. Cardiovascular toxicity has emerged as a previously unrecognized, mechanism-based effect of COX-2 inhibitors. Lessons learned from the many facets of the coxib failure story may help guiding the successful development of a new class of safer NSAIDs, targeting mediators unrelated to arachidonic acid metabolism or molecular targets downstream of COX-isozymes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 59, Issue 5, May 2009, Pages 285–289
نویسندگان
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