کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561494 1126926 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?
چکیده انگلیسی

Till date, the pharmaceutical industry has failed to bring effective and safe disease modifying osteoarthritic drugs (DMOADs) to the millions of patients suffering from this serious and deliberating disease. We provide a review of recent data reported on the investigation of DMOADs in clinical trials, including compounds inhibiting matrix-metalloproteinases (MMPs), bisphosphonates, cytokine blockers, calcitonin, inhibitors of inducible nitric oxide synthase (iNOS), doxycycline, glucosamine, and diacereine.We discuss the challenges associated with the drug development process in general and with DMOADs in particular, and we advance the need for a new development paradigm for DMOADs. Two central elements in this paradigm are a stronger focus on the biology of the joint and the application of new and more sensitive biomarkers allowing redesign of clinical trials in osteoarthritis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 58, Issue 1, July 2008, Pages 1–7
نویسندگان
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