کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2562919 1127320 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers
چکیده انگلیسی

AimThe nerve growth factor is a soluble protein produced by and acting upon a number of different cells located in the nervous, endocrine and immune systems. Recent studies have shown that nerve growth factor (NGF) exerts a critical role on epithelial cells and fibroblasts under normal and pathological conditions. In this review, we present data prospecting the clinical potentiality of NGF in cutaneous and ocular “non-healing” chronic ulcers.Data synthesisA consistent number of in vitro and in vivo studies carried out on animal models and in humans indicated that fibroblasts and epithelial cells are receptive to the action of NGF and that NGF promotes skin and cornea ulcer healing. These observations lead to the hypothesis that NGF can be a potential useful pharmacological agent for clinical investigations.ConclusionThe available clinical evidences suggest that the topical application of NGF promotes healing action without side effects on corneal and cutaneous tissues damaged by chemical, physical and surgical insults and autoimmune disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 57, Issue 4, April 2008, Pages 253–258
نویسندگان
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