کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2562920 1127320 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiangiogenic effects of flavonoids and chalcones
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Antiangiogenic effects of flavonoids and chalcones
چکیده انگلیسی

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential in normal developmental processes. Uncontrolled angiogenesis is a major contributor to a number of disease states such as inflammatory disorders, obesity, asthma, diabetes, cirrhosis, multiple sclerosis, endometriosis, AIDS, bacterial infections and autoimmune disease. It is also considered a key step in tumour growth, invasion, and metastasis. Angiogenesis is required for proper nourishment and removal of metabolic wastes from tumour sites. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health.Numerous bioactive plant compounds are recently tested for their antiangiogenic potential. Among the most frequently studied are polyphenols present in fruits and vegetables. Plant polyphenols inhibit angiogenesis and metastasis through regulation of multiple signalling pathways. Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NFκB, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects.This review focuses on the antiangiogenic properties of flavonoids and chalcones and examines underlying mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 57, Issue 4, April 2008, Pages 259–265
نویسندگان
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