کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2563299 | 1127515 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
New targets and approaches in osteosarcoma
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
GM-CSF, granulocyte-macrophage colony-stimulating factor - GM-CSF، عامل granulocyte-macrophage colony stimulatingHER2, human epidermal growth factor receptor 2 - HER2، گیرنده عامل فاکتور رشد اپیدرمی انسان 2IGF, insulin-like growth factor - IGF، فاکتور رشد مانند انسولینmTOR, mammalian target of rapamycin - mTOR، هدف پستانداران رپامایسین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients who present with localized osteosarcoma can be expected to be cured of their disease with surgery and routine chemotherapy. Only 1/3 of patients with metastases detectable at presentation will be cured. These survival trends have stagnated over the past 20 years using conventional chemotherapy. New agents need to be rationally investigated to strive for improvement in the survival of patients diagnosed with osteosarcoma. This manuscript will review the rationale for conventional chemotherapy used in the treatment of osteosarcoma, as well as agents in varying stages of development that may have promise for treatment in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 137, Issue 1, January 2013, Pages 89–99
Journal: Pharmacology & Therapeutics - Volume 137, Issue 1, January 2013, Pages 89–99
نویسندگان
Jonathan Gill, Manpreet K. Ahluwalia, David Geller, Richard Gorlick,