کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2563488 1560948 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-hormonal male contraception: A review and development of an Eppin based contraceptive
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Non-hormonal male contraception: A review and development of an Eppin based contraceptive
چکیده انگلیسی

Developing a non-hormonal male contraceptive requires identifying and characterizing an appropriate target and demonstrating its essential role in reproduction. Here we review the development of male contraceptive targets and the current therapeutic agents under consideration. In addition, the development of EPPIN as a target for contraception is reviewed. EPPIN is a well characterized surface protein on human spermatozoa that has an essential function in primate reproduction. EPPIN is discussed as an example of target development, testing in non-human primates, and the search for small organic compounds that mimic contraceptive antibodies; binding EPPIN and blocking sperm motility. Although many hurdles remain before the success of a non-hormonal male contraceptive, continued persistence should yield a marketable product.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 157, January 2016, Pages 105–111
نویسندگان
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