کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2564211 | 1127624 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: l-Arginine transporters in cardiovascular disease: A novel therapeutic target l-Arginine transporters in cardiovascular disease: A novel therapeutic target](/preview/png/2564211.png)
The amino acid l-arginine participates in a variety of key biochemical and physiological activities, including its well-recognized role as the key substrate for nitric oxide (NO) biosynthesis. The current review describes the cellular influences on arginine metabolism with particular focus on the transport of l-arginine in the endothelium. It details the processes by which intracellular and extracellular levels of l-arginine may influence nitric oxide production and further documents the imbalance that is evident in various cardiovascular disease states. In man, impairment of l-arginine transport has been observed in hypertension, heart failure, and renal disease, and it may thus be a relevant therapeutic target for rectification of nitric oxide pathogenesis in these conditions.
Journal: Pharmacology & Therapeutics - Volume 116, Issue 3, December 2007, Pages 428–436