کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2564211 1127624 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
l-Arginine transporters in cardiovascular disease: A novel therapeutic target
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
l-Arginine transporters in cardiovascular disease: A novel therapeutic target
چکیده انگلیسی

The amino acid l-arginine participates in a variety of key biochemical and physiological activities, including its well-recognized role as the key substrate for nitric oxide (NO) biosynthesis. The current review describes the cellular influences on arginine metabolism with particular focus on the transport of l-arginine in the endothelium. It details the processes by which intracellular and extracellular levels of l-arginine may influence nitric oxide production and further documents the imbalance that is evident in various cardiovascular disease states. In man, impairment of l-arginine transport has been observed in hypertension, heart failure, and renal disease, and it may thus be a relevant therapeutic target for rectification of nitric oxide pathogenesis in these conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 116, Issue 3, December 2007, Pages 428–436
نویسندگان
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