A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach

Our results suggest that asthma is associated with MKK3 over-expression in CD8+ cells. We have also demonstrated that MKK3 may be critical for airway neutrophilia, but not eosinophilia, suggesting that this may be a target worthy of further consideration in the context of diseases associated with neutrophil activation such as severe asthma and COPD.