کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567535 1128335 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GC–MS determined cotinine in an epidemiological study on smoking status at delivery
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
GC–MS determined cotinine in an epidemiological study on smoking status at delivery
چکیده انگلیسی

The objective of this study was to measure the plasma cotinine levels in pregnant women and their newborns using a gas chromatography–mass spectrometry (GC–MS) method in an epidemiological-delivered population with a wide range of tobacco intakes. Nearly 1000 pregnant women from regional maternity wards (n=1007) were selected for the study. Each patient kept a tobacco diary and underwent a blood test to assess cotinine levels and at the same time that the newborns’ cordonal plasma was taken. These values were then cross-checked.Cotinine was estimated using a selected-ion monitoring mode with a 1.5 ng/ml quantification limit. The cotinine levels in mothers and newborns were highly correlated, whatever the mother's smoking status, with a calculated cut-off for cotinine levels in active smokers of 21.5 ng/ml. Finally, the cotinine determined through this GC–MS method offered a sensitive and accurate measure of tobacco exposition of the pregnant women and their babies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 21, Issue 3, June 2008, Pages 485–488
نویسندگان
, , , , , , , ,