کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567574 1128337 2008 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Using guinea pigs in studies relevant to asthma and COPD
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Using guinea pigs in studies relevant to asthma and COPD
چکیده انگلیسی

The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 21, Issue 5, October 2008, Pages 702–720
نویسندگان
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