کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567927 1128359 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of mexiletine on action potential discharge and conduction in nodose Aδ afferent neurons innervating guinea pig isolated trachea
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Influence of mexiletine on action potential discharge and conduction in nodose Aδ afferent neurons innervating guinea pig isolated trachea
چکیده انگلیسی

Local anesthetics are among the most effective peripherally acting antitussives. A complete understanding of their pharmacological properties in airway afferent neurons associated with the cough reflex has been hampered by an incomplete understanding of the contribution of various classes of afferent neuron to cough. The aim of this study was to evaluate the influence of the antitussive local anesthetic mexiletine on nodose ganglion-derived vagal afferent Aδ-fibers innervating guinea pig trachea. This distinct subtype of airway sensory neuron was recently shown to be involved in evoking cough in anaesthetized guinea pigs. The current findings demonstrate that a concentration of mexiletine sufficient to inhibit citric acid- or mechanically-induced action potential initiation at the nerve ending did not block action potential conduction along axons. These findings are indicative of differences in sensitivity to local anesthetics of highly specialized regions of afferent neurons involved in initiation or conduction of impulses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 19, Issue 4, August 2006, Pages 258–263
نویسندگان
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