کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567930 1128359 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Formoterol induces tolerance to the bronchodilating effect of Salbutamol following methacholine-provocation test in asthmatic children
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Formoterol induces tolerance to the bronchodilating effect of Salbutamol following methacholine-provocation test in asthmatic children
چکیده انگلیسی

ObjectivesTo study whether Formoterol treatment affect the bronchodilator response to salbutamol after methacholine-provocation test (MPT) in asthmatic children.Study designA prospective, double-blind, randomized, placebo-controlled study. Children aged 7–16 years with mild-persistent to moderate asthma treated with inhaled corticosteroids, were enrolled. After 2-weeks of run-in period, subjects were randomized to inhaled Formoterol 9 μg bid (n=19) or placebo (n=19) for 2 weeks. MPT with salbutamol-recovery curve was performed at the beginning and at the end of the trial period. Measurements of peak expiratory flow rate (PEFR), symptoms score, rescue bronchodilator usage and side effects were recorded daily. The primary end-points were the change in FEV1 0–10 min after salbutamol inhalation and the recovery time from 80 to 100% of pretest FEV1. Statistical analyses were performed by ANOVA with repeated measures.ResultsThere was a decrease in the bronchodilator response to salbutamol and an improved PEFR in the Formoterol group. There was no difference in all other parameters.ConclusionFormoterol decreases the bronchodilator response to salbutamol following MPT. Whether this phenomenon has clinical implication during acute asthma needs further studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 19, Issue 4, August 2006, Pages 281–285
نویسندگان
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