کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2568449 | 1128451 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diethylene glycol-induced toxicities show marked threshold dose response in rats
ترجمه فارسی عنوان
سمیت های ناشی از دی اتیلن گلیکول واکنش آستانه دوزهای آشکار در موش صحرایی نشان می دهد
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کلمات کلیدی
اسید دیالیکولیک، مدل حیوانی، ارزیابی ریسک، نفوذپذیری، سمیت کبد،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Diethylene glycol (DEG) exposure poses risks to human health because of widespread industrial use and accidental exposures from contaminated products. To enhance the understanding of the mechanistic role of metabolites in DEG toxicity, this study used a dose response paradigm to determine a rat model that would best mimic DEG exposure in humans. Wistar and Fischer-344 (F-344) rats were treated by oral gavage with 0, 2, 5, or 10Â g/kg DEG and blood, kidney and liver tissues were collected at 48Â h. Both rat strains treated with 10Â g/kg DEG had equivalent degrees of metabolic acidosis, renal toxicity (increased BUN and creatinine and cortical necrosis) and liver toxicity (increased serum enzyme levels, centrilobular necrosis and severe glycogen depletion). There was no liver or kidney toxicity at the lower DEG doses (2 and 5Â g/kg) regardless of strain, demonstrating a steep threshold dose response. Kidney diglycolic acid (DGA), the presumed nephrotoxic metabolite of DEG, was markedly elevated in both rat strains administered 10Â g/kg DEG, but no DGA was present at 2 or 5Â g/kg, asserting its necessary role in DEG-induced toxicity. These results indicate that mechanistically in order to produce toxicity, metabolism to and significant target organ accumulation of DGA are required and that both strains would be useful for DEG risk assessments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology and Applied Pharmacology - Volume 282, Issue 3, 1 February 2015, Pages 244-251
Journal: Toxicology and Applied Pharmacology - Volume 282, Issue 3, 1 February 2015, Pages 244-251
نویسندگان
Greg M. Landry, Cody L. Dunning, Fleurette Abreo, Brian Latimer, Elysse Orchard, Kenneth E. McMartin,