Organic anion transporting polypeptides in the hepatic uptake of PBDE congeners in mice

► PBDE congeners are substrates of OATPs expressed in human hepatocytes. ► Mice are commonly used to study the toxicity of chemicals like the PBDE congeners. ► Oatp1a4, Oatp1b2, and Oatp2b1 transported all three PBDE congeners in vitro. ► In vivo Oatp1a4 plays a minor and Oatp1b2 a major role in BDE47 liver accumulation.