Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers

► In our study, the mean SMI for workers came from arsenic plants is 4.06, so they may be in danger. ► There are more MMA, there are more damage of exon 5 of p53 gene. ► MMA and damage of exon 5 of p53 gene may be useful biomarkers to assess adverse health effects caused by arsenic.