Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells

► Goniothalamin (GTN) induced apoptosis in hepatocellular carcinomas-derived cells. ► The apoptosis induced by GTN is PMAIP1-dependent, regardless of TP53 status. ► The apoptosis induced by GTN might be TP53 transcription-dependent or -independent. ► GTN-induced apoptosis is mitochondria- and caspases-mediated.