Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis

► The human T lymphocyte cell line Jurkat was exposed to TBTO. ► Whole-genome microarray experiments were performed. ► Data analysis revealed the induction of ER stress and activation of NFAT and NFKB. ► Exposure to TBTO also led to T cell activation, oxidative stress and apoptosis.