کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572690 1129319 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Current treatment strategies for inhibiting mTOR in cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Current treatment strategies for inhibiting mTOR in cancer
چکیده انگلیسی


• We delineate the roles of mTOR in the biology of healthy and cancer cells.
• We focus on the current therapeutic strategies used to inhibit mTOR.
• We highlight the mechanisms of resistance to mTOR inhibitors.
• We discuss the major challenges in the clinical use of mTOR inhibitors.

Mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that regulates a wide range of functions, including cell growth, proliferation, survival, autophagy, metabolism, and cytoskeletal organization. mTOR activity is dysregulated in several human disorders, including cancer. The crucial role of mTOR in cancer cell biology has stimulated interest in mTOR inhibitors, placing mTOR on the radar of the pharmaceutical industry. Several mTOR inhibitors have already undergone clinical trials for treating tumors, without great success, although mTOR inhibitors are approved for the treatment of some types of cancer, including advanced renal cell carcinoma. However, the role of mTOR inhibitors in cancer treatment continues to evolve as new compounds are continuously being disclosed. Here we review the three classes of mTOR inhibitors currently available for treating cancer patients. Moreover, we highlight efforts to identify markers of resistance and sensitivity to mTOR inhibition that could prove useful in the emerging field of personalized medicine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 36, Issue 2, February 2015, Pages 124–135
نویسندگان
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