کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2572787 1129328 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epigenetic mechanisms of importance for drug treatment
ترجمه فارسی عنوان
مکانیزم های اپیزیونیک اهمیت برای درمان دارویی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Epigenetic modifications are induced by drugs and other xenobiotics.
• Epigenomic variations cause altered drug responses.
• Epigenomic biomarkers can aid in drug therapy.

There are pronounced interindividual variations in drug metabolism, drug responses, and the incidence of adverse drug reactions. To a certain extent such variability can be explained by genetic factors, but epigenetic modifications, which are relatively scarcely described so far, also contribute. It is known that a novel class of drugs termed epidrugs intervene in the epigenetic control of gene expression, and many of these are now in clinical trials for disease treatment. In addition, disease prognosis and drug treatment success can be monitored using epigenetic biomarkers. Here we review these novel aspects in pharmacology and address intriguing future opportunities for gene-specific epigenetic editing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 35, Issue 8, August 2014, Pages 384–396
نویسندگان
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