کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574125 1561249 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Participation of the TRP channel in the cardiovascular effects induced by carvacrol in normotensive rat
چکیده انگلیسی

Carvacrol has been described as an agonist/antagonist of different transient receptor potential (TRP) channels and voltage-dependent calcium channels (Cavs). The aim of this study was to evaluate the role of Cav and TRP channels following carvacrol stimulation. Initially, in mesenteric artery rings carvacrol relaxed phenylephrine-induced contractions. Furthermore, carvacrol inhibited contraction elicited by CaCl2 in depolarizing nominally without Ca2 + medium and antagonized the contractions induced by S(−)-Bay K 8644 and inhibited Ca2 + currents indicating the inhibition of Ca2 + influx through L-type Cav. Additionally, carvacrol antagonized the contractions induced by CaCl2 in the presence of nifedipine/Cyclopiazonic acid/phenylephrine or nifedipine/Cyclopiazonic acid/KCl 60, suggesting a possible inhibition of calcium influx by store operated channels (SOCs), receptor operated channels (ROCs) and/or TRP channels. Interestingly, among the TRP channel blockers used, the effect induced by carvacrol was attenuated by Mg2 + and potentiated by La3 + and Gd3 +, suggesting that TRP channels are involved in relaxation induced by carvacrol. Monoterpene also induced hypotension and bradycardia in non-anesthetized normotensive rats and negative inotropic and chronotropic effects. In conclusion, these results suggest that the hypotensive effect of carvacrol is probably due to bradycardia and a peripheral vasodilatation that involves, at least, the inhibition of the Ca2 + influx through Cav and TRP channels.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volumes 67–69, April–June 2015, Pages 48–58
نویسندگان
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