کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2574499 | 1561275 | 2009 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Role of cyclooxygenase in vasodilation of retinal blood vessels induced by bradykinin in Brown Norway rats Role of cyclooxygenase in vasodilation of retinal blood vessels induced by bradykinin in Brown Norway rats](/preview/png/2574499.png)
We investigated the role of cyclooxygenase (COX) in bradykinin (BK)-induced vasodilation of retinal blood vessels in Brown Norway rats using a novel in vivo fluorescent fundus imaging technique. Under artificial ventilation, the animals were treated with tetrodotoxin, and the decreased blood pressure and heart rate were adjusted to the normal ranges by infusing pressor agents. Diameters of retinal blood vessels contained in the fluorescent fundus images were measured. Intravenous infusion of BK (1–30 µg/kg/min) increased diameters of retinal blood vessels and decreased blood pressure in a dose-dependent manner. The retinal vasodilator responses to BK were significantly attenuated by treatment with either indomethacin, a non-selective COX inhibitor, or nimesulide, a selective COX-2 inhibitor, but not with SC-560, a selective COX-1 inhibitor. These COX inhibitors failed to affect the depressor responses to BK. Under conditions of nitric oxide (NO) synthase blockade with NG-nitro-l-arginine methyl ester, no inhibitory effects of indomethacin on BK-induced vasodilation of retinal blood vessels were observed. These results suggest that the vasodilator effects of BK on retinal blood vessels are partly mediated through a COX-2-dependent pathway in Brown Norway rats. The prostanoid-dependent component of BK-induced retinal vasodilator response seems to be mediated by a mechanism that involves NO.
In Brown Norway rats, the retinal vasodilator responses to BK were significantly attenuated by treatment with either Indomethacin, a non-selective COX inhibitor, or Nimesulide, a selective COX-2 inhibitor, but not with SC-560, a selective COX-1 inhibitor. These COX inhibitors failed to affect the depressor responses to BK.Figure optionsDownload as PowerPoint slide
Journal: Vascular Pharmacology - Volume 51, Issues 2–3, August–September 2009, Pages 119–124