کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2574669 | 1129706 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urinary bladder urothelium: Molecular sensors of chemical/thermal/mechanical stimuli
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
The identification of functional receptors/ion channels in bladder urothelial cells and the involvement of these sensor molecules in the release of chemical mediators (nitric oxide, NO; ATP) suggest that urothelial cells exhibit specialized sensory and signaling properties. Such mechanisms could allow these cells to respond to their chemical and physical environments and to engage in reciprocal communication with neighboring urothelial cells as well as nerves in the bladder wall. These and other findings highlight the functional importance of the urinary bladder urothelium and suggest that perturbations in urothelial targets and/or cell–cell interactions may lead to a number of urinary tract abnormalities.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 45, Issue 4, October 2006, Pages 221–226
Journal: Vascular Pharmacology - Volume 45, Issue 4, October 2006, Pages 221–226
نویسندگان
Lori A. Birder,