کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2574801 | 1561282 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of nitric oxide donor and nitric oxide synthase inhibitor on the resistance, exchange and capacitance functions of the canine intestinal vasculature
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
In the present study, we determined the vascular functions using a canine model of isolated intestinal segment perfused with constant flow. The effects of an NO donor, S-nitroso-N-acetylpenicillamine (SNAP) and an NO synthase inhibitor, NÏ-nitro-l-arginine methyl ester (l-NAME) on the vascular factors (resistance, exchange and capacitance) were evaluated. In condition of venous pressure at 0 mmHg, we determined and calculated arterial pressure (Pa) and capillary pressure (Pc). Vascular factors including total, pre- and post-capillary resistance (RT, Ra and Rv), vascular compliance (VC) and capillary filtration coefficient (Kfc) were obtained. SNAP at doses 10â 6 to 10â 4 mol/l produced vasodilatory effects. It dose-dependently reduced the Pa, Pc, RT and Ra, as well as the Ra/Rv ratio. The Rv was slightly decreased. This agent increased the vascular capacity, VC and Kfc. NO inhibition with l-NAME (10â 6 to 10â 4 mol/l) produced the opposite effects. The vasoconstrictory effects of l-NAME increased Pa, Pc, RT and Ra as well as the Ra/Rv ratio. It slightly raised the Rv. l-NAME reduced the vascular capacity, VC and Kfc. The effects of l-NAME were also dose-dependent. This study has provided a detailed data of the vasodilatory and vasoconstrictory effects NO donation and inhibition on vascular factors in the intestinal vasculature.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 48, Issues 2â3, FebruaryâMarch 2008, Pages 122-128
Journal: Vascular Pharmacology - Volume 48, Issues 2â3, FebruaryâMarch 2008, Pages 122-128
نویسندگان
Nan-Kuang Hsieh, Huai-Ren Chang, Cheng-Tao Hu, Hsing I. Chen,