کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574895 1129721 2006 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pharmacogenetics and cardiac ion channels
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Pharmacogenetics and cardiac ion channels
چکیده انگلیسی

Ion channels control electrical excitability in living cells. In mammalian heart, the opposing actions of Na+ and Ca2+ ion influx, and K+ ion efflux, through cardiac ion channels determine the morphology and duration of action potentials in cardiac myocytes, thus controlling the heartbeat. The last decade has seen a leap in our understanding of the molecular genetic origins of inherited cardiac arrhythmia, largely through identification of mutations in cardiac ion channels and the proteins that regulate them. Further, recent advances have shown that ‘acquired arrhythmias’, which occur more commonly than inherited arrhythmias, arise due to a variety of environmental factors including side effects of therapeutic drugs and often have a significant genetic component. Here, we review the pharmacogenetics of cardiac ion channels—the interplay between genetic and pharmacological factors that underlie human cardiac arrhythmias.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 44, Issue 2, February 2006, Pages 90–106
نویسندگان
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