کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574965 1129727 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis
چکیده انگلیسی

Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto β-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel + bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto β-boswellic acids (10 mg/kg/d) inhibited the Matrigel + bFGF-induced angiogenesis significantly (P < 0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 46, Issue 5, May 2007, Pages 333–337
نویسندگان
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