کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2575180 | 1129740 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Locally administered antiproliferative drugs inhibit hypercontractility to serotonin in balloon-injured pig coronary artery
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کلمات کلیدی
5-HTmTOR5-hydroxytryptamineLCXVascular relaxation - آرامش عروقیBalloon injury - آسیب بالونVascular contraction - انقباض عروقیrestenosis - تنفسAntiproliferative - ضد انفوزیونleft circumflex coronary artery - عروق کرونر چپ چپIntramuscular - عضلانیfarnesyl transferase - فارنزیل ترانسفرازLAD - لادوi.m. - من هستم.mammalian target of rapamycin - هدف پستانداران رپامایسینleft anterior descending coronary artery - چپ قدامی نزولی عروق کرونر
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Although drugs such as sirolimus and paclitaxel are effective in reducing restenosis, their effects on vascular function are often overlooked. In this study, we have examined the effects of local delivery of several anti-restenotic drugs given in vivo after balloon injury on in vitro vascular contraction and relaxation 28 days after injury. Paclitaxel (50 μM), the farnesyl protein transferase inhibitor L744 (25 μM), sirolimus (25 μM) and Van 10/4 (decahydro-1,1,4,7-tetramethyl-1H-cycloprop[e]azulen-4-o-[2-(3-methylpent-2-enoyl)-fucopyranoside]; 25 μM) were delivered to porcine coronary arteries in vivo and the arteries removed 28 days later. Contractions to KCl and 5-hydroxytryptamine (5-HT) and relaxations to calcimycin and 3-morpholinosydnonimine (SIN-1) were measured in control (LCx) and balloon-injured (LAD) rings. In vehicle-infused coronary arteries, contraction to KCl and 5-HT was significantly enhanced 28 days after balloon injury, while the response to calcimycin had recovered fully, indicating endothelial regrowth. The response to SIN-1 was unchanged. None of the four drugs tested had any effect on the enhanced response to KCl 28 days after injury or on recovery of the calcimycin response. The hyper-responsiveness to 5-HT was eliminated by sirolimus, Van 10/4 and L744, but not paclitaxel. This study demonstrates that local drug infusion with structurally different antiproliferative drugs at the time of balloon angioplasty does not affect endothelial recovery and may in some cases prevent hyper-responsiveness to constrictor agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 44, Issue 5, May 2006, Pages 363-371
Journal: Vascular Pharmacology - Volume 44, Issue 5, May 2006, Pages 363-371
نویسندگان
Simon Kennedy, Roger M. Wadsworth, Cherry L. Wainwright,