Development of Mesoscopic Simulation Studies on Nonionic Block Copolymer Surfactants

Nonionic block copolymer surfactants, possessing a low stimulation and a low toxicity, have been widely used as pharmaceutical excipients. Studies are conducted on surfactants mainly through experiments. However, through this method, it is difficult to study the solubilization mechanism of surfactants. Mesoscopic simulation, with a shorter period and a lower cost, was beneficial for the study of mechanisms; provided guidelines for experiments and applications; and was, thus, favored by researchers. In recent years, numerous studies have been carried out on nonionic block copolymer surfactants. This article reviewed the effect of mesoscopic simulations on nonionic block copolymer surfactants, aiming at providing an effective method for the study on the mechanism and application of nonionic block copolymer surfactants.