Research Status and Methods of Rationality of Daily Oral Administration Times of Traditional Chinese Medicine Preparations

The rationality of daily oral administration times of traditional Chinese medicine (TCM) is a key scientific problem on its safety and efficacy in clinical application. In this article, the current research situation and essentiality of daily oral administration times of TCM were stated. One evaluation pattern was put forward on the basis of pharmacodynamic/pharmacokinetic (PD-PK) and mainly on the basis of pharmacodynamic biomarkers (PD-Markers).