Combined Research of Si wu tang and Blood Deficiency

Combined research on prescriptions and zheng hou sets up a bridge between theory and therapy in traditional Chinese medicine (TCM). Based on Si wu tang (SWT) and blood deficiency (BD), three BD animal models were induced by 60Co irradiation, cyclophospha- mide, or chronic bleeding. Factors such as circulating blood cells, the ability of colony-forming unit of bone marrow cells, CD34+ count, cell cycle, and apoptosis play important roles in the pathogenesis and development of BD. Based on pharmacology mechanism research on the entire body, tissue, cell and molecular level, polysaccharide, paeoniflorin, tetramethylpyrazine, and ferulic acid were found to be hematopoietic constituents of SWT. And hematopoietic cytokines are also involved in hematopoietic mechanism of SWT.