Effects of Qingkailing Injection on Transforming Growth Factor-β1 Expression in Cerebral Ischemia-reperfusion Injury in Rats

ObjectiveTo explore the effects of Qingkailing injection (QKL) on transforming growth factor-β1 (TGF-β1) expression in the rats with cerebral ischemia-reperfusion injury.MethodsHealthy Wistar rats were randomly divided into 3 groups: normal group, model group, and QKL-treated group. Model of cerebral ischemia-reperfusion injury was copied by repeated occlusion of common carotid arteries (CCA) on both sides. The expression of glial fibrillary acidic protein (GFAP) and TGF-β1 in brain tissue was observed at different time intervals, using immunity histochemistry staining method.ResultsAt different time intervals after cerebral ischemia-reperfusion injury, the expression of GFAP and TGF-β1 in brain tissue increased by different degrees, whereas QKL decreased them by different degrees.ConclusionQKL could probably reduce the expression of TGF-β1 by restraining the activity of astrocytes (AST).