Variety of natural products derived from tryptophan and stereoselective synthesis of tetrahydro-β-carboline derivatives of pharmacological importance

The use of chiral inductors belonging to different classes of compounds is elaborated. Tetrahydro-β-carboline derivatives were constructed stereoselectively by the use of (R)-1-arylethylamine and l-amino acids. Asymmetric transfer hydrogenation was proven highly effective in enantioselective synthesis of several alkaloids.