کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2583742 | 1130701 | 2014 | 10 صفحه PDF | دانلود رایگان |
• We studied placental oxidative status in rural residents and in a control group.
• Placental carboxylesterase activity significantly decreased in pulverization period.
• Enzymatic and non-enzymatic antioxidants showed no changes in pulverization period.
• Catalase activity was inversely associated to placental index in this period.
• Placental catalase may serve as a potential biomarker of susceptibility to pesticides.
The impact of environmental organophosphate pesticide exposure on the placenta oxidative status was assessed. Placental samples were collected from women residing in an agricultural area during pesticide pulverization period, non-pulverization period and from control group. Carboxylesterase activity was significantly decreased in pulverization period group. Enzymatic and non-enzymatic defense system, the oxidative stress biomarkers and the nuclear factor erythroid 2-related factor levels showed no differences among groups. However, in the pulverization period group, an inverse association between catalase activity and placental index, a useful metric for estimating placental inefficiency, was found. This result suggests that catalase may serve as a potential placental biomarker of susceptibility to pesticides. Further studies designed from a gene-environment perspective are needed.
Journal: Environmental Toxicology and Pharmacology - Volume 38, Issue 1, July 2014, Pages 220–229