کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583830 1130704 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro protective effects of pyrroloquinoline quinone on methylmercury-induced neurotoxicity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
In vitro protective effects of pyrroloquinoline quinone on methylmercury-induced neurotoxicity
چکیده انگلیسی

Methylmercury (MeHg), as a well-known neurotoxicant, has been implicated to induce massive neurodegeneration. Pyrroloquinoline quinone (PQQ) is a novel redox cofactor and also exists in various plants and animal tissues. In vivo as well as in vitro experimental studies have shown that PQQ functions as an essential nutrient or antioxidant. In this study, we demonstrated the protective effects of PQQ on MeHg-induced neurotoxicity in PC12 cells. The results showed that after pretreatment of PC12 cells with PQQ prior to MeHg exposure, the MeHg-induced cytotoxicity was significantly attenuated, and then DNA fragmentation was correspondingly reduced. PQQ prevented the disruption of mitochondrial membrane potential, up-regulated the level of Bcl-2, and consequently inhibited the activation of caspase-3. Moreover, PQQ also decreased the production of ROS and maintained the GSH levels in PC12 cells exposed to MeHg. Thus, these data indicate that PQQ can protect neurons against MeHg-induced apoptosis and oxidative stress via ameliorating the mitochondrial dysfunction. Data from this study provide a new useful strategy for the treatment of neuronal toxicity induced by mercury toxins.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 27, Issue 1, January 2009, Pages 103–110
نویسندگان
, , , , , ,