کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2591533 1131814 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal exposure to bisphenol A and phthalates and infant neurobehavior
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Prenatal exposure to bisphenol A and phthalates and infant neurobehavior
چکیده انگلیسی

ObjectiveTo examine the association of prenatal exposure to bisphenol A and select common phthalates with infant neurobehavior measured at 5 weeks.MethodsWe compared the concentration of maternal urinary metabolites of bisphenol A and phthalates at two distinct time points in pregnancy (16w, 26w) with scores on the NICU Network Neurobehavioral Scale (NNNS) at 5 weeks of age in a cohort of 350 mother/infant pairs.ResultsPrenatal exposure to BPA was not significantly associated with neurobehavioral outcomes at 5 weeks. Significant associations between prenatal exposure to measured phthalates and infant neurobehavioral outcomes differed by type of phthalate and were only seen with exposure measured at 26 weeks. Higher total di-butyl phthalate (DBP) metabolites at 26w were associated with improved behavioral organization evidenced by decreased arousal (p = .04), increased self-regulation (p = .052), and decreased handling (p = .02). In males, higher total di-2-ethylhexyl phthalate (DEHP) metabolites at 26w were associated with more nonoptimal reflexes (p = .02).ConclusionThe association between prenatal phthalate exposure and infant neurobehavior differed by type of phthalate and was evident only with exposure measured at 26w. Prenatal exposure to DBP was associated with improved behavioral organization in 5-week-old infants. Prenatal exposure to DEHP was associated with nonoptimal reflexes in male infants. There was no evidence of an association between prenatal BPA exposure and infant neurobehavior.


► DBP at 26w gestation was linked with improved behavioral organization in infants.
► DEHP at 26w gestation was linked with more non-optimal reflexes in male infants.
► BPA during gestation was not associated with infant neurobehavior.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 33, Issue 5, September–October 2011, Pages 558–566
نویسندگان
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