کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2591633 1131819 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prenatal exposure to diclofenac sodium changes the morphology of the male rat cervical spinal cord: A stereological and histopathological study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Prenatal exposure to diclofenac sodium changes the morphology of the male rat cervical spinal cord: A stereological and histopathological study
چکیده انگلیسی

Diclofenac sodium is one of the most commonly used non-steroidal anti-inflammatory drugs. It may cause alteration in the nervous system during neuronal development. However, there is no investigation concerning its role in the cervical spinal cord. Pregnant rats were divided into two groups, namely drug-treated and control (saline-injected) groups. To obtain the offspring of the drug-treated group, a dose of 1 mg/kg daily diclofenac sodium (Voltaren, 75 mg/3 ml ampoule, Novartis) was injected into the pregnant rats beginning from the 5th day after mating to the 20th day of the pregnancy. To obtain the control group of offspring, serum physiological at a 1 ml/kg daily dose was injected into the pregnant control rats during the same period. Male offspring were obtained after delivery and each group was divided into two subgroups: 4-week-old and 20-week-old. The total neuron number in diclofenac sodium-treated rats was significantly lower than in the control group animals. The total volume of the cervical spinal cord segments (C1–C4) was also estimated. There was a significant difference between the volumes of the two groups, especially in the 20-week-old subgroup. This may suggest that development of neurons and volume of cervical spinal cord are affected in prenatal animals after administration of diclofenac sodium.

Research Highlights
► Prenatal exposure of diclofenac sodium.
► Suppressing the new formation of neuron in spinal cord.
► Decreasing neuron number in the ventral and dorsal horn of spinal cord and its volume.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 33, Issue 2, March–April 2011, Pages 282–287
نویسندگان
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