کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592313 1132002 2013 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluating the male and female reproductive toxicity of high-boiling petroleum substances
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Evaluating the male and female reproductive toxicity of high-boiling petroleum substances
چکیده انگلیسی


• Observed no reproductive effects in rat dermal reproductive studies of two HBPS.
• Found little evidence of reproductive effects in 39 rat dermal repeat-dose studies.
• Found little evidence of reproductive effects in 59 rat dermal develop studies.
• Concluded HBPS have low potential to cause reproductive vs. systemic or dev toxicity.

To meet the EPA HPV Chemical Challenge Program requirement for reproductive toxicity data on sponsored high-boiling petroleum substances (HBPS), an analysis was conducted using the results of 39 repeat-dose and 59 developmental rat dermal toxicity studies on HBPS samples spanning the boiling range of the sponsored substances, and the results of three one-generation reproductive toxicity studies on two samples spanning the concentration range of polycyclic aromatic compounds of sponsored substances. The analysis found little evidence of male or female reproductive tract toxicity based on histopathology, reproductive organ weight, and sperm parameters, and no evidence of effects on fertility, while significant developmental toxicity and/or systemic repeat-dose toxicity were frequently observed. Among 14 samples of HBPS tested in both repeat-dose toxicity and developmental toxicity studies, there were no studies in which an adverse reproductive tract finding occurred at a dose lower than that producing developmental toxicity or other adverse effects in repeat-dose toxicity studies. The current analysis supports the hypothesis that effects in developmental and/or repeat-dose toxicity studies of HBPS occur at doses lower than those that might affect fertility in rat one-generation reproductive studies. When adequate developmental and repeat-dose toxicity studies are available, a reproductive toxicity study of HBPS appears unnecessary.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 67, Issue 2, Supplement, 1 November 2013, Pages S60–S74
نویسندگان
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