کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592552 1132027 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Statistical evaluation of the Local Lymph Node Assay
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Statistical evaluation of the Local Lymph Node Assay
چکیده انگلیسی

In the Local Lymph Node Assay measured endpoints for each animal, such as cell proliferation, cell counts and/or lymph node weight should be evaluated separately. The primary criterion for a positive response is when the estimated stimulation index is larger than a specified relative threshold that is endpoint- and strain-specific. When the lower confidence limit for ratio-to-control comparisons is larger than a relevance threshold, a biologically relevant increase can be concluded according to the proof of hazard. Alternatively, when the upper confidence limit for ratio-to-control comparisons is smaller than a tolerable margin, harmlessness can be concluded according to a proof of safety.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 56, Issue 3, April 2010, Pages 352–356
نویسندگان
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