کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2592589 | 1132032 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The French approach to deriving toxicity reference values: An example using reprotoxic effects
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The French approach to deriving toxicity reference values: An example using reprotoxic effects The French approach to deriving toxicity reference values: An example using reprotoxic effects](/preview/png/2592589.png)
چکیده انگلیسی
Abnormal development of foetuses and infants, together with impairment of reproduction were considered to be critical effects. Where critical windows of exposure were concerned, quantitative analysis suggested the need for several types of toxicity reference value, as a function of exposure duration: reprotoxic effects may result from acute or chronic exposure at any time of life, whilst developmental effects may occur after exposure during the pregnancy or during the lactation period. The choice of a critical study is based on epidemiological or toxicological quality criteria. The working group recommends the use of the benchmark dose approach in estimating the critical dose. Finally, the working group considered the application of uncertainty factors typically used to take into account the variability between animal and human, between different individuals, and the availability of the data.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 55, Issue 3, December 2009, Pages 353-360
Journal: Regulatory Toxicology and Pharmacology - Volume 55, Issue 3, December 2009, Pages 353-360
نویسندگان
Frédéric Dor, Luc Multigner, Blandine Doornaert, Dominique Lafon, Cédric Duboudin, Pascal Empereur-Bissonnet, Patrick Lévy, Nathalie Bonvallot,