کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592682 1132038 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimating tar and nicotine exposure: Human smoking versus machine generated smoke yields
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Estimating tar and nicotine exposure: Human smoking versus machine generated smoke yields
چکیده انگلیسی

ObjectiveDetermine human smoked (HS) cigarette yields of tar and nicotine for smokers using their own brand in their everyday environment.MethodA robust, filter analysis method was used to estimate the tar and nicotine yields for 784 subjects. Seventeen brands were chosen to represent a wide range of styles: 85 and 100 mm lengths; menthol and non-menthol; 17, 23, and 25 mm circumference; with tar yields [Federal Trade Commission (FTC) method] ranging from 1 to 18 mg. Tar bands chosen corresponded to yields of 1–3 mg, 4–6 mg, 7–12 mg, and 13+ mg.ResultsA significant difference (p < 0.0001) in HS yields of tar and nicotine between tar bands was found. Machine-smoked yields were reasonable predictors of the HS yields for groups of subjects, but the relationship was neither exact nor linear. Neither the FTC, the Massachusetts (MA) nor the Canadian Intensive (CI) machine-smoking methods accurately reflect the HS yields across all brands. The FTC method was closest for the 7–12 mg and 13+ mg products and the MA method was closest for the 1–3 mg products. The HS yields for the 4–6 mg products were approximately midway between the FTC and the MA yields. HS nicotine yields corresponded well with published urinary and plasma nicotine biomarker studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 56, Issue 1, February 2010, Pages 100–110
نویسندگان
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