کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592772 1132045 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Axilla surface area for males and females: Measured distribution
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Axilla surface area for males and females: Measured distribution
چکیده انگلیسی

With the recent introduction of exposure-based Quantitative Risk Assessment (QRA) as an approach to the evaluation, of materials in finished consumer products that are potential dermal sensitizers, the need for robust exposure data was clearly identified. The objective of this current study is to provide a value for the axilla surface area (SA) that is statistically derived and can be used in dermal sensitization QRA for ingredients of personal care products meant for use on the axilla. The axilla surface area measured for 60 men and 60 women resulted in a median surface area for a single axilla of 64.5 cm2 for females and 135.5 cm2 for males. These participants were representative of the United States population in their range of heights and weights. Furthermore, combining these surface area data with measured use data from this and other studies has enabled calculations of consumer exposure to solid APDO products on a dose/unit area/day basis (9.1 mg/cm2/d).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 52, Issue 1, October 2008, Pages 46–52
نویسندگان
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