کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592841 1132050 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toxicological analysis points to a lower tolerable daily intake of melamine in food
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Toxicological analysis points to a lower tolerable daily intake of melamine in food
چکیده انگلیسی

Intensified food safety concern over melamine has prompted national authorities to assess its tolerable daily intake (TDI) for protection of general population including young children. TDI is calculated by dividing a no-observed-adverse-effect level (NOAEL) by a safety factor (SF). Based on appropriate choices of values, the US Food and Drug Administration determined two TDI values in the unit of mg per kg body weight per day as first 0.63 and then 0.063, while the World Health Organization, 0.5 and then 0.2, as a result of increasing the SF values in calculation. We used a similar procedure, with judicious selection of pertinent values, to obtain a TDI of 0.0081. Arguments in support of this lower TDI value were provided to alert the international community.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 55, Issue 1, October 2009, Pages 13–16
نویسندگان
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