کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593310 1562155 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The treatment of epilepsy in pregnancy: The neurodevelopmental risks associated with exposure to antiepileptic drugs
ترجمه فارسی عنوان
درمان صرع در دوران بارداری: خطرات عصبی مرتبط با قرار گرفتن در معرض داروهای ضدصرع
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Data on the neurodevelopmental outcomes of children exposed to AEDs lags behind investigations into risk of major congenital malformation.
• Accumulated data highlights a significant and substantial risk to diverse aspects of neurodevelopment associated with prenatal exposure to valproate in a dose dependent manner.
• Overall, children exposed to carbamazepine or lamotrigine are not found to be at increased risk of neurodevelopmental difficulties; however further work is required focused on specific cognitive abilities and possible dose relationships.
• Evidence is limited for newer AEDs and a lack of evidence should not be taken as evidence of safety.
• Given the potential lifetime impact of neurodevelopmental difficulties, neurodevelopment following in utero exposure to AEDs should be a more primary focus in teratology research.

A number of antiepileptic drugs (AEDs) have been confirmed as teratogens due to their association with an increased malformation rate. The majority of research to date does not find an association between prenatal exposure to monotherapy carbamazepine, lamotrigine or phenytoin and neurodevelopmental outcome in comparison to control children and noted higher abilities in comparison to children exposed to valproate; but further work is needed before conclusions can be drawn. Data for levetiracetam was limited to one study, as was the evidence for topiramate. Sodium valproate exposure appeared to carry a dose dependent risk to the developing brain, with evidence of reduced levels of IQ, poorer verbal abilities and increased rate of autistic spectrum disorder both in comparison to control children and children exposed to other AEDs. The severity of the neurodevelopmental deficits associated with prenatal exposure to valproate highlight the critical need to consider neurodevelopmental outcomes as a central aspect of teratological research.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 64, September 2016, Pages 203–210
نویسندگان
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