کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593487 1562169 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal nicotine exposure during gestation and lactation induces cardiac remodeling in rat offspring
ترجمه فارسی عنوان
قرار گرفتن در معرض نیکوتین مادر در دوران بارداری و شیردهی، تغییرات قلب را در فرزندان موش ایجاد می کند
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Cardiac remodeling is characterized by collagen deposition and heart hypertrophy.
• Nicotine exposure during gestation and lactation induces cardiac remodeling in rat.
• TGF-β1 may be involved in the pathogenesis of cardiac remodeling.

The aim of this study was to evaluate the effects of maternal nicotine exposure on heart morphology and fibrosis in rat offspring. Nicotine was administered to pregnant Sprague-Dawley rats by using a subcutaneous osmotic mini-pump at a dose of 6 mg/kg/day from Gestational Days 7–21 or Gestational Day 7 to Postnatal Day 14. A control group received an equal volume of saline by the same route as nicotine. Rats born to prenatal nicotine-treated dams exhibited significantly greater cell width of cardiomyocytes, fewer cardiomyocyte nuclei number, higher β-myosin heavy chain and transforming growth factor (TGF-β1) expression, and higher collagen deposition in heart compared with rats born to normal saline-treated dams on Postnatal Days 7 and 21. Postnatal nicotine exposure further enhances these effects. We conclude that TGF-β1 may be involved in the pathogenesis of cardiac remodeling induced by maternal nicotine exposure during gestation and lactation in rat offspring.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 50, December 2014, Pages 4–10
نویسندگان
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