کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593499 1562169 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Esophageal atresia and prenatal exposure to mycophenolate
ترجمه فارسی عنوان
آترزی مری و قرار گرفتن در معرض آن برای مایکوفنولات
کلمات کلیدی
متیفنولات مفتیل، مواد مخدر ناشی از ناهنجاری ها، تراتوژن، آترزی مری
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Mycophenolate is a teratogenic drug. Its clinical pattern is still being delineated.
• We present four cases with esophageal atresia prenatally exposed to mycophenolate.
• Esophageal atresia could be a new feature even without major craniofacial anomalies.
• Mycophenolate may reduce the efficacy of oral contraceptives.

Mycophenolate mofetil is a widely prescribed immunosuppressive agent for transplant patients and autoimmune diseases. Potential teratogenic effects after in utero exposure to mycophenolate mofetil has been described in human clinical observations. The complete clinical pattern is still being delineated. We present four newborns with esophageal atresia and other congenital anomalies, prenatally exposed to mycophenolate mofetil during the first trimester. Two of the cases had other defects related to the embryopathy: microtia, eye abnormalities and oral clefts. Two cases did not show major craniofacial anomalies. We propose that esophageal atresia with or without tracheoesophageal fistula is a feature of mycophenolate embryopathy even without the presence of other major craniofacial anomalies. The human teratogenicity of MMF is reinforced by this report, and the current contraceptive recommendations about its use in fertile women are stressed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 50, December 2014, Pages 117–121
نویسندگان
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