کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2593646 | 1132247 | 2012 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys](/preview/png/2593646.png)
Perfluorooctanesulfonate (PFOS) has been found in biological samples in wildlife and humans. The geometric mean half-life of serum elimination of PFOS in humans has been estimated to be 4.8 years (95% CI, 4.0–5.8). A series of studies was undertaken to establish pharmacokinetic parameters for PFOS in rats, mice, and monkeys after single oral and/or IV administration of K+PFOS. Animals were followed for up to 23 weeks, and pharmacokinetic parameters were determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFOS than monkeys. The serum elimination half-lives in the rodent species were on the order of 1–2 months; whereas, in monkeys, the serum elimination half lives approximated 4 months. Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of body burden in humans on repeated exposure to PFOS and PFOS-generating materials.
► Perfluorooctanesulfonate is found in biological samples from wildlife and humans.
► Pharmacokinetic parameters for PFOS in rats, mice, and monkeys were evaluated.
► Rats and mice appeared to be more effective at eliminating PFOS than monkeys.
► Half-lives in rodents and monkeys approximated 1–2 and 4 months, respectively.
Journal: Reproductive Toxicology - Volume 33, Issue 4, July 2012, Pages 428–440