Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys

Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The human geometric mean serum PFHxS elimination half-life has been estimated to be 2665 days. A series of studies was undertaken to establish pharmacokinetic parameters for PFHxS in rats, mice, and monkeys after single administration with pharmacokinetic parameters determined by WinNonlin® software. Rats and mice appeared to be more effective at eliminating PFHxS than monkeys. With the exception of female rats, which had serum PFHxS elimination half-life of approximately 2 days, the serum elimination half-lives in the rodent species and monkeys approximated 1 month and 4 months, respectively, when followed over extended time periods (10–24 weeks). Collectively, these studies provide valuable insight for human health risk assessment regarding the potential for accumulation of PFHxS in humans.

► Perfluorohexanesulfonate is found in biological samples from wildlife and humans.
► Pharmacokinetic parameters for PFHxS in rats, mice, and monkeys were evaluated.
► Rats and mice appeared to be more effective at eliminating PFHxS than monkeys.
► Female rats had a serum PFHxS elimination half-life of approximately 2 days.
► Half-lives in mice, male rats, and monkeys approximated 1 and 4 months, respectively.