کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593827 1132250 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides
چکیده انگلیسی

Blood cholinesterases and tissue carboxylesterases (CEs) are sensitive indicators of environmental organophosphate pesticides (OPs) exposure. The aim of this pilot study was to assess the impact of OP exposure on placental CE activity and lipid composition. We performed a study of 40 healthy women who live in agricultural farms. Samples were collected during the pulverization period (PP) and recess period (RP). The plasma cholinesterase and placental CE activity decreased in PP, suggesting that women were exposed to OPs and that these pesticides reached the placenta. The cardiolipin content increased and the phosphatidylethanolamine content decreased in the light mitochondrial fraction while total cholesterol and sphingomyelin increased in the nuclear fraction. These changes in lipid profiles suggest repair by hyperplasia of the cytotrophoblast. Decreased CE activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.


► We studied the impact of organophosphate pesticides exposure on maternal blood cholinesterases and placental carboxyesterase activity and lipid composition.
► The plasma cholinesterase and placental carboxylesterase activity decreased associated with organophosphate pulverization period.
► Changes in lipid profiles in light mitochondrial and nuclear fractions suggest repair by hyperplasia of the cytotrophoblast.
► Decreased placental carboxylesterase activity may have clinical and toxicological implications and thus entail potential risks to damage fetal growth and development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 34, Issue 3, November 2012, Pages 402–407
نویسندگان
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