کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593850 1132251 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Zebrafish eleutheroembryos as an alternative system for screening chemicals disrupting the mammalian thyroid gland morphogenesis and function
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Zebrafish eleutheroembryos as an alternative system for screening chemicals disrupting the mammalian thyroid gland morphogenesis and function
چکیده انگلیسی

The importance and irreversibility of the effects of thyroid hormone deficiency on human brain development highlight the importance of identifying environmental agents that interfere with thyroid gland morphogenesis and function. Zebrafish eleutheroembryos are currently used by many pharmaceutical companies in drug discovery as a vertebrate model, not subjected to regulations for animal experiments, that provides an intermediate step between in vitro and rodent assay. The mechanisms of zebrafish thyroid development are generally comparable to those in humans, and moreover, molecular and functional studies of zebrafish thyroid follicles have demonstrated a high degree of conservation with upper vertebrates, opening up the possibility of designing alternative methods for screening individual chemicals and mixtures that impairing thyroid gland morphogenesis and/or function. Analysis of the intrafollicular thyroxine-content of zebrafish larvae exposed to potential disruptors has proved to be a reliable, physiologically relevant endpoint to estimate effects of chemicals on the mammalian thyroid gland.


► Thyroid hormone is essential for mammalian brain development.
► Thyroid gland function disruptors are chemicals impairing thyroid hormone synthesis.
► Zebrafish is commonly used as a vertebrate model in biomedical research.
► We have reviewed the information available on zebrafish thyroid system.
► Zebrafish eleutheroembryo is a model to screen chemicals disrupting the thyroid gland.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 33, Issue 2, April 2012, Pages 188–197
نویسندگان
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