کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594006 1132255 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Preimplantation exposure to bisphenol A (BPA) affects embryo transport, preimplantation embryo development, and uterine receptivity in mice
چکیده انگلیسی

To investigate the effects of bisphenol A (BPA) on embryo and uterine factors in embryo implantation, timed pregnant C57BL6 females were treated subcutaneously with 0, 0.025, 0.5, 10, 40, and 100 mg/kg/day BPA from gestation days 0.5–3.5. In 100 mg/kg/day BPA-treated females, no implantation sites were detected on day 4.5 but retention of embryos in the oviduct and delayed embryo development were detected on day 3.5. When untreated healthy embryos were transferred to pseudopregnant females treated with 100 mg/kg/day BPA, no implantation sites were detected on day 4.5. In 40 mg/kg/day BPA-treated females, delayed implantation and increased perinatal lethality of their offspring were observed. Implantation seemed normal in the rest BPA-treated groups or the female offspring from 40 mg/kg/day BPA-treated group. These data demonstrate the adverse effects of high doses of BPA on processes critical for embryo implantation: embryo transport, preimplantation embryo development, and establishment of uterine receptivity.


► 100 mg/kg/day BPA disrupts embryo transport & development, and uterine receptivity.
► 40 mg/kg/day BPA delays embryo implantation and increases perinatal death.
► 40 and 100 mg/kg/day BPA alters PR expression in gestation day 4.5 uteri.
► BPA at environmentally relevant doses does not appear to affect embryo implantation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 32, Issue 4, December 2011, Pages 434–441
نویسندگان
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